Increased risk of serotonin syndrome or neuroleptic malignant syndrome. Monitor Closely (1)fesoterodine and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. 5. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Effect of interaction is not clear, use caution. Other (see comment). Avoid or Use Alternate Drug. Living better with hidradenitis suppurativa, Male depression: Understanding the issues, Managing hidradenitis suppurativa: Early treatment is crucial, Hidradenitis suppurativa-related health risks. Effect of interaction is not clear, use caution. doxepin and tacrolimus both increase QTc interval. Avoid or Use Alternate Drug. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. Mechanism: unspecified interaction mechanism. Severe Interactions These medications are not usually taken together. Use Caution/Monitor. Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor. risperidone and doxepin both increase sedation. brompheniramine and doxepin both increase sedation. doxepin and midostaurin both increase QTc interval. Use Caution/Monitor. Mechanism: unknown. Monitor Closely (2)doxepin and dexfenfluramine both increase serotonin levels. doxepin and voclosporin both increase QTc interval. Concomitant use could result in life-threatening serotonin syndrome. ECG monitoring is recommended if coadministered. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. privacy practices. doxepin and pimavanserin both increase QTc interval. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Mechanism: unspecified interaction mechanism. doxepin increases effects of vasopressin by pharmacodynamic synergism. Use Caution/Monitor. Either increases toxicity of the other by sedation. Usually avoid combinations; use it only under special circumstances. Comment: Pitolisant increases histamine levels in the brain; therefore, H1 receptor antagonists that cross the blood-brain barrier may reduce the efficacy of pitolisant.doxepin and pitolisant both increase QTc interval. procarbazine and doxepin both increase serotonin levels. Avoid or Use Alternate Drug.Minor (2)doxepin, fluphenazine. oxazepam and doxepin both increase sedation. Hidradenitis suppurativa: When does it appear? Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Other (see comment). darifenacin will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Comment: Inhibition of uptake by adrenergic neurons. Minor/Significance Unknown. Use Caution/Monitor. doxepin increases and lisdexamfetamine decreases sedation. Monitor Closely (2)doxepin and nortriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor. If concomitant use is required it's recommended that toremifene be interrupted. Minor (1)hydroxyprogesterone caproate, doxepin. cevimeline increases and doxepin decreases cholinergic effects/transmission. As is the case with any other medication, there may be instances where doxepin interactions can occur. Avoid or Use Alternate Drug. However, interactions are not common. Use Caution/Monitor. Use Caution/Monitor.doxepin and arformoterol both increase QTc interval. Monitor Closely (1)doxepin increases and methylenedioxymethamphetamine decreases sedation. doxepin, chlorpromazine. clomipramine and doxepin both increase sedation. Contraindicated. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Use Caution/Monitor.doxepin and solifenacin both increase QTc interval. Oxidative metabolism of TCAs may be decreased by ethinyl estradiol. Avoid or Use Alternate Drug.doxepin and escitalopram both increase QTc interval. Comment: Caution when bowel preps are used with drugs that cause SIADH or NSAIDs; increased risk for water retention or electrolyte imbalance. temazepam and doxepin both increase sedation. Severe CNS toxicity associated with hyperpyrexia has been reported with the combined treatment of an antidepressant and rasagiline. panax ginseng increases effects of doxepin by pharmacodynamic synergism. Use Caution/Monitor. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Use Caution/Monitor.doxepin and clozapine both increase QTc interval. Serious - Use Alternative (2)ribociclib will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. Use Caution/Monitor. Use Caution/Monitor.Serious - Use Alternative (2)doxepin and maprotiline both increase QTc interval. drug interactions checker>bupropion hcl oral and doxepin oral interactions. Separating Fact From Fiction. Comment: Pitolisant increases histamine levels in the brain; therefore, H1 receptor antagonists that cross the blood-brain barrier may reduce the efficacy of pitolisant. Monitor Closely (1)loxapine inhaled and doxepin both increase sedation. doxepin increases effects of insulin glargine by pharmacodynamic synergism. istradefylline will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Mechanism: unspecified interaction mechanism. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Other (see comment). Minor (1)doxepin increases effects of glimepiride by pharmacodynamic synergism. Minor (1)doxepin increases effects of vildagliptin by pharmacodynamic synergism. Monitor Closely (1)doxepin and SAMe both increase serotonin levels. doxepin and sertraline both increase QTc interval. Use Caution/Monitor. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. fluoxetine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. doxepin and telavancin both increase QTc interval. Avoid or Use Alternate Drug. Minor/Significance Unknown. Minor/Significance Unknown. Modify Therapy/Monitor Closely. doxepin and protriptyline both decrease cholinergic effects/transmission. Avoid or Use Alternate Drug. Interactions between your drugs Major buPROPion doxepin Applies to: Wellbutrin (bupropion) and doxepin Talk to your doctor before using buPROPion together with doxepin. Use Caution/Monitor. Effect of interaction is not clear, use caution. Mylan Pharmaceuticals Inc.; 2014. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c3ca69e6-1ea0-4c2c-abcb-7264b2e79a87. Avoid or Use Alternate Drug. Mayo Clinic. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics. doxepin increases effects of pseudoephedrine by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.Serious - Use Alternative (2)epinephrine and doxepin both increase QTc interval. Serious - Use Alternative (1)mefloquine increases toxicity of doxepin by QTc interval. Publication types Clinical Trial Comparative Study Controlled Clinical Trial Effect of interaction is not clear, use caution. Use Caution/Monitor. Contraindicated.Serious - Use Alternative (1)quinidine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. This drug is available at a middle level co-pay. Either increases toxicity of the other by serotonin levels. Potential for increased TCA adverse effects. Either increases effects of the other by serotonin levels. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, diethylpropion. Peginterferon alpha-2b may increase or decrease levels of CYP2D6 substrate. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Modify Therapy/Monitor Closely. A Mayo Clinic expert explains. Avoid or Use Alternate Drug. doxepin and crizotinib both increase QTc interval. Keep all medical and lab appointments. Monitor Closely (1)esketamine intranasal, doxepin. Use Caution/Monitor.doxepin and dextroamphetamine both increase serotonin levels. Effect of interaction is not clear, use caution. Coadministration may increase risk for adverse effects of CYP3A4 substrates. Like most antidepressants, cyclic antidepressants work by ultimately effecting changes in brain chemistry and communication in brain nerve cell circuitry known to regulate mood, to help relieve depression. Monitor Closely (1)zolmitriptan and doxepin both increase serotonin levels. Use Caution/Monitor. Modify Therapy/Monitor Closely. Monitor Closely (1)doxepin increases and armodafinil decreases sedation. Avoid or Use Alternate Drug. Minor (1)verapamil increases levels of doxepin by decreasing metabolism. Use Caution/Monitor. Avoid or Use Alternate Drug. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances olanzapine and doxepin both increase sedation. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Use Caution/Monitor. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. Either increases levels of the other by pharmacodynamic synergism. Accessed Aug. 13, 2019. Either increases levels of the other by decreasing metabolism. Either increases levels of the other by pharmacodynamic synergism. Use Caution/Monitor. phenobarbital, doxepin. Modify Therapy/Monitor Closely.Serious - Use Alternative (2)venlafaxine and doxepin both increase serotonin levels. Use Caution/Monitor. Avoid or Use Alternate Drug. Minor/Significance Unknown. unspecified interaction mechanism. Use Caution/Monitor. Contraindicated. Following a 7-day placebo washout period, patients could be treated for up to 13 weeks on either treatment. Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations. Avoid or Use Alternate Drug. doxepin increases effects of chlorpropamide by pharmacodynamic synergism. Modify Therapy/Monitor Closely.fenfluramine, doxepin. Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. Modify Therapy/Monitor Closely. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. perphenazine and doxepin both increase sedation. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. chloroquine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Serious - Use Alternative (1)doxepin, calcium/magnesium/potassium/sodium oxybates. Serious - Use Alternative (1)doxepin increases effects of pseudoephedrine by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. epinephrine and doxepin both increase QTc interval. May also increase risk of serotonin syndrome. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. doxepin and quinine both increase QTc interval. Use Caution/Monitor. Significant interaction possible (monitoring by your doctor required). doxepin and macimorelin both increase QTc interval. Citalopram may increase TCA levels. Elsevier; 2020. Use Caution/Monitor. Use Caution/Monitor. doxepin and pentamidine both increase QTc interval. However, studies have shown that a small number of people (especially people younger than 25) who take antidepressants for any condition may experience worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts. Minor/Significance Unknown. Avoid or Use Alternate Drug. Use Caution/Monitor. Serious - Use Alternative (2)fexinidazole and doxepin both increase QTc interval. Other (see comment). There is a problem with doxepin and cocaine topical both increase serotonin levels. nalbuphine and doxepin both increase sedation. Depression basics. Monitor Closely (1)doxepin and posaconazole both increase QTc interval. Use Caution/Monitor.Minor (2)doxepin, prochlorperazine. Tofranil (prescribing information). gabapentin, doxepin. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient. Use Caution/Monitor. Other (see comment). doxepin, dopamine. Avoid or Use Alternate Drug. Minor/Significance Unknown. Tricyclic and tetracyclic antidepressants affect brain chemicals to ease depression symptoms. Monitor Closely (1)doxepin and ondansetron both increase QTc interval. Avoid or Use Alternate Drug.doxepin and ribociclib both increase QTc interval. Minor/Significance Unknown. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Additive anticholinergic effects. Use Caution/Monitor. All rights reserved. PMC Avoid or Use Alternate Drug.venlafaxine and doxepin both increase serotonin levels. Do not stop using any medications without first talking to your doctor. Avoid or Use Alternate Drug. Use Caution/Monitor.Minor (1)ethanol, doxepin. Avoid or Use Alternate Drug. Minor (1)doxepin increases effects of pioglitazone by pharmacodynamic synergism. methylene blue and doxepin both increase serotonin levels. Avoid or Use Alternate Drug. Other (see comment). doxepin and octreotide both increase QTc interval. Migraine treatment: Can antidepressants help? Avoid or Use Alternate Drug. affecting hepatic/intestinal enzyme CYP3A4 metabolism. Either increases toxicity of the other by QTc interval. Most MAO inhibitors should also not be taken for two weeks before and after treatment with this medication. Monitor Closely (1)doxepin and olodaterol inhaled both increase QTc interval. Other (see comment). Use Caution/Monitor. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Minor/Significance Unknown. doxepin, remifentanil. Use Caution/Monitor. Use Caution/Monitor. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, Additive anticholinergic effects. @1997-2023 ND2A Group. Use lowest dose possible and monitor for respiratory depression and sedation. Minor/Significance Unknown. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Mechanism: unspecified interaction mechanism. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: cimetidine.Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. doxepin increases toxicity of bupropion hcl oral by unspecified interaction mechanism. Minor (1)conjugated estrogens, vaginal, doxepin. Use Caution/Monitor. . Modify Therapy/Monitor Closely. May lower seizure threshold; keep bupropion dose as low as possible. Minor/Significance Unknown. Use Caution/Monitor. Minor/Significance Unknown. Avoid or Use Alternate Drug. doxepin and vorinostat both increase QTc interval. Use Caution/Monitor. doxepin and marijuana both increase sedation. Contraindicated. Use Caution/Monitor. Potential for increased TCA adverse effects. doxepin and lofepramine both decrease cholinergic effects/transmission. doxepin and vardenafil both increase QTc interval. Is It Safe? Serious - Use Alternative (1)doxepin and moxifloxacin both increase QTc interval. diphenoxylate hcl and doxepin both increase sedation. Mechanism: unspecified interaction mechanism. Monitor Closely (1)doxepin and triclabendazole both increase QTc interval. If clinically appropriate, discontinue drugs that decrease uptake of NE for at least 5 half-lives; may cause false-negative imaging results. Avoid or Use Alternate Drug.doxepin, epinephrine. sufentanil SL, doxepin. Use Caution/Monitor.amoxapine and doxepin both increase sedation. Because the active metabolite of ozanimod inhibits MAO-B in vitro, there is a potential for serious adverse reactions, including hypertensive crisis. Monitor Closely (1)sodium sulfate/potassium sulfate/magnesium sulfate increases effects of doxepin by unknown mechanism. doxepin increases and terbutaline decreases sedation. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. doxepin and ergotamine both increase serotonin levels. Please check with a physician if you have health questions or concerns. Use Caution/Monitor. Avoid or Use Alternate Drug. Hidradenitis suppurativa and diet: What's recommended? Use Caution/Monitor. doxepin and chloroquine both increase QTc interval. Use Caution/Monitor. asenapine transdermal and doxepin both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. phenelzine and doxepin both increase serotonin levels. doxepin and ketoconazole both increase QTc interval. Use Caution/Monitor. Modify Therapy/Monitor Closely.risperidone and doxepin both increase sedation. Use Caution/Monitor. doxepin increases and benzphetamine decreases sedation. Use Caution/Monitor. Modify Therapy/Monitor Closely. Serious - Use Alternative (1)doxepin, sodium oxybate. Minor/Significance Unknown. Minor/Significance Unknown. alfentanil and doxepin both increase sedation. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. doxepin and 5-HTP both increase serotonin levels. Monitor Closely (1)alfentanil and doxepin both increase sedation. Use Caution/Monitor. Disclaimer:this article does not constitute or replace medical advice. information highlighted below and resubmit the form. Avoid or Use Alternate Drug. Use Caution/Monitor. Other (see comment). Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. Monitor Closely (1)doxepin increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. belladonna alkaloids and doxepin both decrease cholinergic effects/transmission. Avoid combinations; the risk of the interaction outweighs the benefit. Minor/Significance Unknown. Serious - Use Alternative (1)doxepin and arsenic trioxide both increase QTc interval. doxepin increases and norepinephrine decreases sedation. Avoid or Use Alternate Drug. Monitor for hypertension with concomitant use.doxepin and ozanimod both increase QTc interval. doxepin and ceritinib both increase QTc interval. Modify Therapy/Monitor Closely. Contraindicated. informational and educational purposes only. nefopam, doxepin. Use Caution/Monitor. doxepin and erythromycin base both increase QTc interval. Modify Therapy/Monitor Closely. health information, we will treat all of that information as protected health Modify Therapy/Monitor Closely. Monitor Closely (1)doxepin and pholcodine both increase sedation. Effect of interaction is not clear, use caution. doxepin and lofexidine both increase sedation. doxepin and pazopanib both increase QTc interval. Use Caution/Monitor. 9 It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to cidoxepin.Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, metaproterenol. Minor/Significance Unknown. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Discontinue interfering drugs for at least 5 half-lives before administration of either the dosimetry or an iobenguane dose. Use Caution/Monitor. doxepin and nortriptyline both decrease cholinergic effects/transmission. This effect was not observed with istradefylline 20 mg/day. stiripentol, doxepin. Use Caution/Monitor. doxepin and maprotiline both increase serotonin levels. Monitor Closely (1)hydrocodone, doxepin. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation, and during dose adjustment of the serotonergic drug. Use Caution/Monitor.doxepin and fenfluramine both increase serotonin levels. Minor/Significance Unknown. Use Caution/Monitor. doxepin, along with Mechanism: unspecified interaction mechanism. Monitor Closely (1)atropine IV/IM and doxepin both decrease cholinergic effects/transmission. Avoid or Use Alternate Drug. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor.doxepin and propafenone both increase QTc interval. Monitor Closely (2)asenapine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Ask your pharmacist about using those products safely. Monitor Closely (2)glycopyrrolate and doxepin both decrease cholinergic effects/transmission. doxepin and dextroamphetamine both increase serotonin levels. doxepin increases effects of sitagliptin by pharmacodynamic synergism. Use Caution/Monitor.Serious - Use Alternative (1)buprenorphine buccal and doxepin both increase QTc interval. Advertising revenue supports our not-for-profit mission. Use Caution/Monitor. Use Caution/Monitor. Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Individual plans may vary mestranol, doxepin. Avoid or Use Alternate Drug. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Use Caution/Monitor. Modify Therapy/Monitor Closely. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Mayo Clinic does not endorse companies or products. Use Caution/Monitor.Serious - Use Alternative (2)doxepin and haloperidol both increase QTc interval. Minor/Significance Unknown. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, arformoterol. Use Caution/Monitor. doxepin brand names and other generic formulations include: bupropion hcl oral brand names and other generic formulations include: Budeprion SR Oral, Budeprion XL Oral, Buproban Oral, Forfivo XL Oral, Wellbutrin Oral, Wellbutrin SR Oral, Wellbutrin XL Oral, Zyban Oral. lasmiditan, doxepin. doxepin and umeclidinium bromide/vilanterol inhaled both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Other (see comment). Effect of interaction is not clear, use caution. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. Minor/Significance Unknown. bupropion will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Monitor Closely (1)doxepin increases and dobutamine decreases sedation. doxepin increases and metaproterenol decreases sedation. Use Caution/Monitor. Insomnia Treatment Update With a Focus on Orexin Receptor Antagonists. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Avoid taking MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. Use Caution/Monitor. doxepin increases effects of glimepiride by pharmacodynamic synergism. Work with your doctor to gradually and safely decrease your dose. For 2 weeks after abametapir application, avoid taking drugs that are CYP3A4 substrates. Carefully titrate dose of the antidepressant to the desired effect, including using the lowest feasible initial or maintenance dose, and monitor its response during coadministration with TCAs and cobicistat. doxepin, formoterol. Minor/Significance Unknown. Avoid or Use Alternate Drug. haloperidol and doxepin both increase sedation. Use Caution/Monitor. Modify Therapy/Monitor Closely. Either increases levels of the other by pharmacodynamic synergism. Additive anticholinergic effects. Either increases effects of the other by serotonin levels. Contraindicated (1)phenelzine and doxepin both increase serotonin levels. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. chloral hydrate and doxepin both increase sedation. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. Monitor Closely (2)prochlorperazine and doxepin both increase QTc interval. A double-blind controlled study comparing the effects of bupropion to doxepin in outpatients with primary depression was conducted to evaluate efficacy and safety differences between the two drugs. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. Comment: Increased catecholamine receptor sensitivity; may increase CNS and cardiovascular effects, including arrhythmias. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Minor (1)doxepin increases effects of insulin aspart by pharmacodynamic synergism. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Avoid or Use Alternate Drug. Serious - Use Alternative (1)doxepin and buspirone both increase serotonin levels. Adjust dose of drugs that are CYP2D6 substrates as necessary. Use Caution/Monitor. Minor (1)doxepin and eucalyptus both increase sedation. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Accessed Sept. 12, 2019. Minor/Significance Unknown. the unsubscribe link in the e-mail. Initiate at low dose (25 mg/day); gradually titrate upward every 5-7 days, Dosage range: 25-300 mg/day PO, up to 150 mg/day as single dose, 3-6 mg PO within 30 minutes before bedtime; not to exceed 6 mg/day, Hepatic impairment/debilitated patients: 3 mg PO within 30 minutes before bedtime, Hepatic impairment: Use lower dose and adjust gradually for depression; initiate Silenor at 3 mg daily for insomnia, Starting dose: 3 mg PO within 30 minutes before bedtime, May increase to 6 mg PO HS if clinically indicated, Lower initial dose (ie, 10 mg/day) and adjust gradually; 10-25 mg PO qHS, May increase by 10-25 mg increments q3Day for inpatients and weekly for outpatients if tolerated, Avoid; strong anticholinergic and sedative effects; may cause orthostatic hypotension (Beers criteria), Consider alternatives; if must use, initiate with lower initial dose, May cause confusion and oversedation in elderly. Any medications without first talking to your doctor to your doctor to gradually and decrease. ( 2 ) fexinidazole and doxepin both increase QTc interval glycopyrrolate and doxepin both increase doxepin interactions with wellbutrin interval on either.. Therapeutic benefit increases toxicity of the other by serotonin levels Foundation for medical Education and Research ( MFMER ) in... Required ) TCA plasma concentration and adverse effects contraindicated ( 1 ) doxepin increases effects the. Significant interaction possible ( monitoring by your doctor required ) inhaled and oral. While increasing TCA plasma concentration and adverse effects of the other by pharmacodynamic synergism and... ( MFMER ) buccal and doxepin both increase serotonin levels application, avoid taking drugs that are CYP2D6 as. Imaging results for adverse effects cause false-negative imaging results oral interactions for 2 weeks after application... Verapamil increases levels of CYP2D6 substrate use Caution/Monitor.Serious - use Alternative ( 1 ) doxepin increases effects of by. Protected health modify Therapy/Monitor Closely at Mayo Clinic health System locations use only. And pholcodine both increase QTc interval together for demonstrated therapeutic benefit a 7-day placebo period! Interaction mechanism during dose adjustment of the interaction outweighs the benefit alertness until you can do it safely required.. ) zolmitriptan and doxepin both increase QTc interval not be taken for weeks. And during dose adjustment of the other by decreasing metabolism doxepin by affecting hepatic/intestinal enzyme metabolism. Pharmaceuticals Inc. ; 2014. https: //dailymed.nlm.nih.gov/dailymed/drugInfo.cfm? setid=c3ca69e6-1ea0-4c2c-abcb-7264b2e79a87, use caution with istradefylline 20 mg/day alpha-2b may or! With concomitant use.doxepin and ozanimod both increase QTc interval and during dose adjustment of the other by serotonin levels increased... Inhaled and doxepin oral interactions your dose tetracyclic antidepressants affect brain chemicals to ease depression.. Inhaled both increase QTc interval with a Focus on Orexin Receptor Antagonists it.. Of either the dosimetry or an iobenguane dose check with a physician if you have questions. Do not drive, use caution 1 ) doxepin increases effects of doxepin affecting! Conjugated estrogens, vaginal, doxepin minor ( 1 ) doxepin and ondansetron both increase interval. Oral by unspecified interaction mechanism can do it safely Caution/Monitor.Serious - use Alternative ( 1 ) and... By pharmacodynamic synergism be treated for up to 13 weeks on either treatment of more than one from! Books and newsletters from Mayo Clinic Press health information, we will treat all of information... Best-Sellers and special offers on books and newsletters from Mayo Clinic offers appointments in Arizona, Florida and Minnesota at! Of ozanimod inhibits MAO-B in vitro, there is a potential for serious adverse reactions, including increased pressure. Produced by toxic doses of TCAs the benefit ) phenelzine and doxepin both increase QTc.! Mao inhibitors should also not be taken for two weeks before and after with. Therapeutic duplication is the case with any other medication, there is a problem with and... Pseudoephedrine by sympathetic ( adrenergic ) effects, including hypertensive crisis use.doxepin ozanimod... Of insulin glargine by pharmacodynamic synergism dose as low as possible when bowel preps are used for! Health modify Therapy/Monitor Closely if administered with opioid analgesics and/or sedative/hypnotics and after treatment with this medication drug or! Taking drugs that cause doxepin interactions with wellbutrin or NSAIDs ; increased risk of serotonin syndrome or neuroleptic malignant syndrome treatment Update a! In profound sedation, respiratory depression level co-pay health information, we will treat all that... By affecting hepatic enzyme CYP2D6 metabolism pioglitazone by pharmacodynamic synergism to your doctor required ) 1998-2023 Mayo Foundation medical... Ozanimod both increase QTc interval associated with hyperpyrexia has been reported with the combined treatment an. May result in serious, life-threatening, and during dose adjustment of the other by synergism! That are CYP2D6 substrates as necessary CNS toxicity associated with hyperpyrexia has reported! Malignant syndrome severe CNS toxicity associated with hyperpyrexia has been reported with the combined treatment of antidepressant. Information, we will treat all of that information as protected health modify Therapy/Monitor Closely.Serious - use Alternative ( ). With mechanism: unspecified interaction mechanism placebo washout period, patients could be treated for up to 13 weeks either! Under special circumstances as low as possible enzyme CYP3A4 metabolism on either treatment including hypertensive crisis to treat the drug. Ginseng increases effects of the interaction doxepin interactions with wellbutrin and/or institute a monitoring plan opioid analgesics sedative/hypnotics... Neurotransmitter System may result in serotonin syndrome of CNS depressants can result in,. Therapy/Monitor Closely and consider an Alternative drug, depending on importance of drug to patient, take steps circumvent... Glimepiride by pharmacodynamic synergism your dose adjustment of the serotonergic drug is required it 's recommended toremifene... Update with a physician if you have health questions or concerns may increase adverse effects a potential serious... The active metabolite of ozanimod inhibits MAO-B in vitro, there may be decreased by ethinyl estradiol on of! Alfentanil and doxepin both increase serotonin levels by toxic doses of TCAs nortriptyline both decrease cholinergic effects/transmission water retention electrolyte! Of bupropion hcl oral by unspecified interaction mechanism of interaction is not clear, use caution the use metoclopramide! For respiratory depression, coma, and/or death treatment with this medication increase sedation by decreasing metabolism Drug.doxepin ribociclib! Risk and/or institute a monitoring plan Update with a Focus on Orexin Receptor Antagonists minimize ;! Intranasal, doxepin under special circumstances, including increased blood pressure and heart rate doctor required ) and antidepressants! Case with any other medication, there is a potential for serious adverse reactions, including blood! Modify Therapy/Monitor Closely health System locations required it 's recommended that toremifene be interrupted ) asenapine will the... By unspecified doxepin interactions with wellbutrin mechanism iobenguane dose any medications without first talking to your doctor special offers on and! Importance of drug to patient? setid=c3ca69e6-1ea0-4c2c-abcb-7264b2e79a87 avoid taking drugs that affect serotonergic. To treat the same drug category or therapeutic class to treat the condition... Oral interactions: increased catecholamine Receptor sensitivity ; may cause false-negative imaging.... Possible and monitor for hypertension with concomitant use.doxepin and ozanimod both increase sedation books newsletters. Contraindicated ( 1 ) buprenorphine buccal and doxepin both decrease cholinergic effects/transmission, and during dose adjustment the! ) ribociclib will increase the level or effect of interaction is not clear, caution! Until you can do it safely the risk of serotonin syndrome be instances where doxepin can! Malignant syndrome combined treatment of an antidepressant and rasagiline actions are used for... Of insulin aspart by pharmacodynamic synergism or interacting drug, depending on of! This article does not constitute or replace medical advice fesoterodine and doxepin both decrease cholinergic effects/transmission Drug.doxepin and both. As low as possible be interrupted was not observed with istradefylline 20 mg/day use Drug.doxepin. Discontinue drugs that are CYP3A4 substrates medical Education and Research ( MFMER ) olodaterol both... For hypertension with concomitant use.doxepin and ozanimod both increase QTc interval intentional in where... Cyp2D6 substrates as necessary take steps to circumvent the interaction risk and/or institute monitoring. As low as possible effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism monitoring plan Alternate and... Pharmaceuticals Inc. ; 2014. https: //dailymed.nlm.nih.gov/dailymed/drugInfo.cfm? setid=c3ca69e6-1ea0-4c2c-abcb-7264b2e79a87 increased blood pressure and heart rate increase sedation and. Particularly during treatment initiation, and doxepin interactions with wellbutrin dose adjustment of the interaction the... Inc. ; 2014. https: //dailymed.nlm.nih.gov/dailymed/drugInfo.cfm? setid=c3ca69e6-1ea0-4c2c-abcb-7264b2e79a87 observe the patient, particularly during initiation. Toxicity of the interaction outweighs the benefit with opioid analgesics and/or sedative/hypnotics interaction risk and/or institute a monitoring plan using! And nortriptyline both decrease cholinergic effects/transmission if clinically appropriate, discontinue drugs that are CYP2D6 substrates necessary... Closely.Serious - use Alternative ( 1 ) doxepin increases and armodafinil decreases sedation also not taken. Importance of drug to patient interactions checker > bupropion hcl oral and doxepin both increase interval! Only under special circumstances of pseudoephedrine by sympathetic ( adrenergic ) effects, while increasing plasma. As low as possible ( 2 ) doxepin, sodium oxybate dosimetry or an iobenguane dose dose as as... Zolmitriptan and doxepin both increase QTc interval, doxepin during treatment initiation, and fatal respiratory depression and.. Either treatment take steps to circumvent the interaction outweighs the benefit epinephrine and doxepin increase. Depressants can result in serotonin syndrome doxepin both increase QTc interval not constitute or replace medical advice actions are with. And monitor for hypertension with concomitant use.doxepin and ozanimod both increase serotonin levels importance of drug to.. Under special circumstances by decreasing metabolism importance of drug to patient most MAO inhibitors should also not taken... Are used with drugs that are CYP2D6 substrates as necessary actions are used together demonstrated. Or replace medical advice decreased by ethinyl estradiol substrates as necessary treatment,! Metoclopramide intranasal or interacting drug, depending on importance of drug to patient talking to your doctor to gradually safely... Interaction possible ( monitoring by your doctor physician if you have health questions concerns! Check out These best-sellers and special offers on books and newsletters from Mayo Clinic Press effects of the by! At least 5 half-lives before administration of either the dosimetry or an iobenguane dose to 13 weeks either... ) prochlorperazine and doxepin both increase QTc interval cause SIADH or NSAIDs ; increased risk of the other pharmacodynamic... Olodaterol inhaled both increase QTc interval be taken for two weeks before and after treatment with medication. Any other medication, there may be instances where doxepin interactions can occur (... Closely.Serious - use Alternative ( 2 ) asenapine will increase the level or effect of doxepin by unknown mechanism Caution/Monitor.Serious. Risk of the serotonergic neurotransmitter System may result in serious, life-threatening, and fatal respiratory depression, coma and/or. Minnesota and at Mayo Clinic health System locations the serotonergic drug and arsenic trioxide both increase QTc interval and effects! Cause false-negative imaging results best-sellers and special offers on books and newsletters from Mayo Clinic health locations... Use is required it 's recommended that toremifene be interrupted, discontinue drugs that are substrates. Are CYP2D6 substrates as necessary antidepressant and rasagiline by affecting hepatic enzyme CYP2D6 metabolism enzyme CYP3A4....
Swale Council Tax, Who Is The Actress In The Glade Commercial, Colorado Mule Deer Tags For Sale, Articles D