Pathogenesis of high-altitude pulmonary edema: inflammation is not an etiologic factor. HAPE has been extensively linked to increased pulmonary artery pressures and subsequent exudative pulmonary edema. Treatment for HAPE involves treating the underlying pulmonary hypertension. 2020;46:315–328. 2020;pbaa002. [Pathophysiology, prevention and therapy of altitude pulmonary edema]. There is far too much vasoconstriction and far too great a rise in pulmonary artery pressure, all of which lead fluid to leak out of the blood vessels into the lung tissue, but this occurs with no inflammation.”, “In lung injury due to COVID-19, the virus attacks the cells that make up the air sacs of the lungs. 2021 Jan 11:1-14. doi: 10.1080/07391102.2020.1868340. The aim of this article is to outline a perspective on the pathophysiology of COVID-19 in the context of the currently available clinical data published in the literature. Immunotoxic Effects of PFCs: Implications for the COVID Vaccine? The utilization of medications found to be effective in HAPE, for the treatment of COVID-19, is proposed. Given the medical emergency of a growing contagion and the thousands of lives at stake, expedient attempts to improve survival are needed. In light of this, a countermeasure that has been shown to be effective in the analogous condition of HAPE is Acetazolamide. These fundamental differences necessitate different treatment approaches. COVID-19 Lung Injury is Not High Altitude Pulmonary Edema. This causes fluid to leak from the blood vessels to the lung tissues and eventually into the air sacs. Dr. Luks and his co-authors warn that without careful scrutiny, misinformation can quickly spread. Traveler’s Diarrhea: Prevention and Treatment, New Method for Studying Mitochondrial DNA and Function, MRI May Be Able to Confirm PTSD Following Traumatic Event. Last Updated: December 17, 2020. This causes fluid to leak from the blood vessels to … Exp Ther Med. Early reports of COVID-19 symptoms and the compelling need to quickly identify treatment options and curb the growing number of critically ill patients have led to erroneous and potentially dangerous comparisons between COVID-19 and other respiratory diseases like high altitude pulmonary edema, or HAPE. Note that the coronavirus disease 2019 (COVID-19) pandemic has raised concerns over whether affected patients with respiratory distress have … This corrects the root cause of HAPE, hypoxic pulmonary vasoconstriction. doi: 10.7759/cureus.10230. HHS Huang C, Wang Y, Li X, et al. This applies to both outpatient and inpatient COVID-19 treatment, and when COVID-19 is the primary diagnosis. Node considers health to be a reflection of the relationships a person or a business has with themselves, with God and with those around them. Heterogeneous Perfusion in COVID-19 and High Altitude Pulmonary Edema: A Review of Two Cases Followed by Implications for Hypoxic Pulmonary Vasoconstriction, Thrombosis Development, Ventilation Perfusion Mismatch and Emergence of Treatment Approaches. These fundamental differences necessitate different treatment approaches. Viral mediated inflammation; Alveolar epithelial inflammation/dysfunction; Impaired surfactant function/alveolar fluid clearance; Alveolar collapse and/or filling (V/Q mismatch) Wang M, Zhou Y, Zong Z, et al. European Respiratory Journal 2020. Author Disclosure Statement None of the authors have any conflicts of interest or financial interests to report regarding the material presented in this manuscript. Monteiro AC, Suri R, Emeruwa IO, Stretch RJ, Cortes-Lopez RY, Sherman A, Lindsay CC, Fulcher JA, Goodman-Meza D, Sapru A, Buhr RG, Chang SY, Wang T, Qadir N. PLoS One. 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